Project Units 3-4

Microbiology Units 3-4- Microbiology (BIOL 246)

Late penalty of 10% per day late including weekends

Disease Comparison - Describe and Evaluate The Distinctions in Disease Manifestations in Individuals/Populations for Epidemic/Pandemic Actions

In this project you will use real data to compare and contrast an historical disease (see table below for assigned disease) with COVID- 19 for the content listed below for Units 3-4.  You will use primary literature and other reputable sources to compile this information in detail. You will create a SINGLE static (ie- it isn’t an item that can be changed after submission) digital product to represent this work (Prezi, Powerpoint, digital book, digital poster, etc.). For each disease (COVID-19 and the assigned disease), you will determine the following items, then you will compare/contrast the two diseases. Be specific, detailed, and thorough in your analysis. *You will need to provide a works cited list on the last page with appropriate citations within your text/images, or you will receive a 0 for the assignment for an academic integrity violation.

You will submit in TWO locations.

1. Canvas Assignment - This is your project grade in the “Test” category. HERE
2. Canvas Discussion Board - Peer review and disease dialog for the project as a separate grade from the project.

1. Genetics (compare and contrast details of your assigned item and COVID-19)
   1. Morphology & Structure
   2. Sequence/Genetic distinctions for strain(s)
      1. As a tool in this effort, you may BLAST the strain for the sequence(s), but you may also use primary literature to discern strain information within your assigned item and COVID-19
2. Epidemiology of Pathogen (compare and contrast details of your assigned item and COVID-19)
   1. For the last outbreak, list the population(s) affected, location(s) of infection, and timeframes for studying the epidemic(s)
   2. Explain the transmission of the pathogen
3. Pathogenicity of Pathogen (compare and contrast details of your assigned item and COVID-19)
   1. Explain the portal(s) of entry and exit, adherence to the host, pathogen load for invasion, potential evasion from the host, and the specific effect(s) on the host
4. Immune Response by Host (specific for this pathogen) (compare and contrast details of your assigned item and COVID-19)
   1. Innate
   2. Adaptive
5. Therapeutics, Design and Development (Drugs and Vaccines specific for this pathogen) (compare and contrast details of your assigned item and COVID-19)
   1. Type(s) of vaccines available and drug classes utilized
   2. Specificity & Sensitivity (Effectiveness) of Each therapeutic
   3. Solubility (ie- how does the therapeutic enter the system- oral, injection, etc.- for functionality? What about the design ensures this?)
   4. Target-Host Effect (How do you ensure the therapeutic only targets the pathogen? Why are host cells not affected?)
6. Public Health Campaign (compare and contrast details of your assigned item and COVID-19)
   1. Explain the methods currently used to educate the public about this pathogen.
   2. Explain any modifications to enhance these initiatives to meet the goal of understanding.
7. References